Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.
Emilio Nuñez-BorqueSergio Fernandez-BravoPablo Rodríguez Del RíoEbrahim Mohammed AlwashaliDavid Lopez-DominguezMaria Dolores Gutierrez-BlazquezJose Julio LagunaJaime Tome-AmatJulio Gallego-DelgadoAlicia Gomez-LopezDiana BetancorJavier Cuesta-HerranzMaria Dolores Ibáñez SandínAlberto Benito-MartínVanesa EstebanPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
These findings provide, for the first time, some insights into the anaphylactic miRNA serum profile in children and point to miR-21-3p and miR-487b-3p as candidate biomarkers. Furthermore, the SBA revealed a possible implication of these molecules in the underlying molecular mechanisms. Moreover, ECs increased miR-21-3p intracellularly and released it to the environment in response to anaphylaxis.