Investigation of Causal Effects of Protein Biomarkers on Cardiovascular Disease in Persons with HIV.
Cavan S ReillyÁlvaro H BorgesJason V BakerSandra E SafoShweta SharmaMark N PolizzottoJames S PankowXiaojun HuBrad T ShermanAbdel G BabikerJens D LundgrenHenry Clifford LanePublished in: The Journal of infectious diseases (2022)
These results implicate inflammatory and fibrotic processes as contributing to CVD. While some of these biomarkers are well established in the general population and in PLWH (IL6 and its receptor), some are novel to PLWH (HGF, AXL and GAS6) and some are novel overall (CLEC6A). Further investigation into; 1.) the uniqueness of these biomarkers in PLWH and 2.) the role of these biomarkers as targets among PLWH, is warranted.