The Physiology of Homeoprotein Transduction.
Ariel A Di NardoJulia FuchsRajiv L JoshiKenneth L MoyaAlain ProchiantzPublished in: Physiological reviews (2019)
The homeoprotein family comprises ~300 transcription factors and was long seen as primarily involved in developmental programs through cell autonomous regulation. However, recent evidence reveals that many of these factors are also expressed in the adult where they exert physiological functions not yet fully deciphered. Furthermore, the DNA-binding domain of most homeoproteins contains two signal sequences allowing their secretion and internalization, thus intercellular transfer. This review focuses on this new-found signaling in cell migration, axon guidance, and cerebral cortex physiological homeostasis and speculates on how it may play important roles in early arealization of the neuroepithelium. It also describes the use of homeoproteins as therapeutic proteins in mouse models of diseases affecting the central nervous system, in particular Parkinson disease and glaucoma.
Keyphrases
- dna binding
- parkinson disease
- cell migration
- transcription factor
- deep brain stimulation
- mouse model
- optic nerve
- single cell
- cell therapy
- subarachnoid hemorrhage
- public health
- functional connectivity
- cerebrospinal fluid
- stem cells
- cerebral ischemia
- mesenchymal stem cells
- brain injury
- cataract surgery
- optical coherence tomography
- genetic diversity