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Use of an emulated trial to investigate the association between use of nitrogen-based bisphosphonates and risk of epithelial ovarian cancer.

Karen M TuesleyKatrina SpilsburyPenelope M WebbSallie-Anne PearsonPeter DonovanMichael D CooryChristopher B SteerLouise M StewartNirmala PandeyaMelinda M ProtaniSuzanne Dixon-SuenLouise Marquart-WilsonSusan J Jordan
Published in: International journal of epidemiology (2024)
Results from our emulated trial suggest that in women who initiated NBB treatment, those who continued use had 13% and 29% lower hazards of being diagnosed with EOC overall and serous EOC, respectively, compared with women who discontinued use.
Keyphrases
  • polycystic ovary syndrome
  • phase iii
  • study protocol
  • clinical trial
  • phase ii
  • pregnancy outcomes
  • high grade
  • cervical cancer screening
  • breast cancer risk
  • metabolic syndrome
  • replacement therapy
  • double blind