Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats.
Taygun C UzuneserEva-Maria WeissJana DahlmannsLiubov S KalinichenkoDavide AmatoJohannes KornhuberChristian AlzheimerJan HellmannJonas KaindlHarald HübnerStefan LöberPeter GmeinerTeja W GrömerChristian P MüllerPublished in: Journal of psychopharmacology (Oxford, England) (2020)
These findings suggest the presynaptic accumulation of HAL may serve as an essential prerequisite for its full antipsychotic action and may explain the time course of APD action. Targeting accumulation properties of APDs may, thus, become a new strategy to improve APD action.
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