Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia.
Ling XuDanlin YaoJiaxiong TanZifan HeZhi YuJie ChenGengxin LuoChunli WangFenfang ZhouXianfeng ZhaShaohua ChenYangqiu LiPublished in: Journal of hematology & oncology (2018)
Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in TSCM and TCM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.
Keyphrases
- acute myeloid leukemia
- induced apoptosis
- cell cycle arrest
- stem cells
- working memory
- allogeneic hematopoietic stem cell transplantation
- endoplasmic reticulum stress
- end stage renal disease
- ejection fraction
- signaling pathway
- bone marrow
- oxidative stress
- acute lymphoblastic leukemia
- cell proliferation
- risk assessment
- peripheral blood
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- chronic kidney disease
- disease activity
- pi k akt
- radiation therapy