Preconceptional paternal caloric restriction of high-fat diet-induced obesity in Wistar rats dysregulates the metabolism of their offspring via AMPK/SIRT1 pathway.
Rachakatla AnuradhaM SrinivasM SatyavaniK SureshM N MuralidharRajender Rao KalashikamPublished in: Lipids in health and disease (2024)
The findings highlight that HFCR-I resulted in paternal undernutrition, impacting the health of offspring, whereas HFCR-II largely restored the effects of a high-fat diet on their offspring. As a result, moderate caloric restriction has emerged as an effective weight loss strategy with minimal implications on future generations. This underscores the shared responsibility of fathers in contributing to sperm-specific epigenetic imprints that influence the health of adult offspring.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- adipose tissue
- weight loss
- skeletal muscle
- metabolic syndrome
- healthcare
- public health
- type diabetes
- mental health
- bariatric surgery
- health information
- dna methylation
- oxidative stress
- current status
- health promotion
- social media
- protein kinase
- young adults
- climate change