Multi-yolk-shell MnO@mesoporous carbon (MnO@m-carbon) nanopomegranates, featuring MnO nanoparticles within cavities of m-carbon with internal space between the MnO nanoparticle and a cavity carbon shell, were subtly constructed. Moreover, the buffer space was well controlled by means of regulating the size of the cavity in m-carbon or the content of MnO. The results of electrochemical measurements demonstrated that MnO(10)@m-carbon(22) nanopomegranates (MnO nanoparticle, 15 nm; cavity size, 22 nm) had the best cycling and rate performance for lithium ion storage. The pomegranate-like MnO@m-carbon nanostructures have shown several advantages for their excellent performance: the nanocavity in m-carbon can restrict the growth and agglomeration of MnO nanoparticles; the well-interconnected mesoporous carbon matrix provides a "highway" for electrons and lithium ion transport; the voids between the MnO nanoparticle and cavity shell can alleviate the volume expansion.