Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein.

Alexandra AlbusMaike GoldJan-Philipp BachMonika Burg-RoderfeldMarit JördensYvonne KirchheinYannick KronimusDavid MengelInga ZerrRichard Dodel

Published in: PloS one (2018)

nAbs-Aβ, nAbs-PrP possibly display comparable affinity to the same structural epitope within Aβ and PrP106-126 A117V whereas the epitope recognized by nAbs-α-Syn is only present in α-Syn. The structural similarity of Aβ and PrP fragment promotes the outline for an efficient antibody for the treatment of several neurodegenerative disorders and extend the functional characteristics of the investigated nAbs.

Keyphrases

platelet rich plasma
systemic lupus erythematosus
monoclonal antibody
binding protein
small molecule
single molecule
smoking cessation