Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency.

Katsumi KadekawaNaoki KawamoritaTakahiro ShimizuMasahiro KurobePhilip S TurnbullSundeep ChandraTakahito KambaraJoanna C BartonAlan J RussellNaoki Yoshimura

Published in: BJU international (2020)

Treatment with SARMs could be a more effective modality for the treatment of SUI than DHT, without affecting bladder function, by enhancing smooth- and striated muscle-mediated urethral function under stress conditions such as sneezing.

Keyphrases

signaling pathway
high glucose
oxidative stress
pi k akt
drug induced