G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder.

Anna M GutridgeMeridith T RobinsRobert J CassellRajendra UpretyKendall L MoresMee Jung KoGavril W PasternakSusruta MajumdarRichard M Van Rijn

Published in: British journal of pharmacology (2020)

Our results suggest that kratom extracts can decrease alcohol intake but still carry significant risk upon prolonged use. Development of more δ opioid-selective synthetic opioids may provide a safer option than kratom to treat alcohol use disorder with fewer side effects.

Keyphrases

alcohol use disorder
chronic pain
pain management
human health
risk assessment
alcohol consumption
weight loss