A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative stress, Cellular, and Molecular Mechanisms.
Maryam GolmohammadiDalia Ahmed ElmaghrabyAndrés Alexis Ramírez-CoronelNodir RakhimovShahad Saad MohammedRosario Mireya Romero-ParraMohammed Abed JawadMohammad Yassin ZamanianAfsaneh SoltaniNiloofar TaheriFarzaneh KianifarNasim VousooghiPublished in: Fundamental & clinical pharmacology (2023)
Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anti-cancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anti-cancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC.
Keyphrases
- oxidative stress
- induced apoptosis
- cell cycle arrest
- dna damage
- endothelial cells
- endoplasmic reticulum stress
- cell death
- signaling pathway
- skeletal muscle
- induced pluripotent stem cells
- cardiovascular events
- single cell
- cardiovascular disease
- mouse model
- type diabetes
- ischemia reperfusion injury
- cell therapy
- dna repair
- free survival