Effect of Ylang-Ylang ( Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo.
Robson Araújo de Freitas JuniorPaloma Kênia de Moraes Berenguel LossavaroCandida Aparecida Leite KassuyaEdgar Julian Paredes-GameroNelson Carvalho Farias JúniorMaria Inês Lenz SouzaFrancielli Maria de Souza Silva-ComarRoberto Kenji Nakamura CumanDenise Brentan SilvaMônica Cristina Toffoli-KadriSaulo Euclides Silva-FilhoPublished in: Molecules (Basel, Switzerland) (2022)
The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang ( Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N -formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties.
Keyphrases
- drug induced
- liver failure
- high glucose
- respiratory failure
- oxidative stress
- inflammatory response
- essential oil
- aortic dissection
- anti inflammatory
- peripheral blood
- hepatitis b virus
- adipose tissue
- skeletal muscle
- escherichia coli
- pseudomonas aeruginosa
- metabolic syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- smoking cessation