Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles.
Vitória Barbosa de SouzaVinícius N da RochaPaulo Cesar PiquiniOtávio Augusto ChavesBernardo Almeida IglesiasPublished in: Molecules (Basel, Switzerland) (2023)
The trans -A 2 B-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysical properties (absorption, emission by steady-state and time-resolved fluorescence) in several solvents and TDDFT calculations, aggregation, photostability and reactive oxygen species generation (ROS), which are relevant when selecting photosensitizers used in photodynamic therapy and many other photo-applications. In addition, we also evaluated the biomolecule-binding properties with CT-DNA and HSA by spectroscopy, viscometry and molecular docking calculations assays.
Keyphrases
- molecular docking
- molecular dynamics simulations
- photodynamic therapy
- reactive oxygen species
- single molecule
- density functional theory
- molecular dynamics
- ionic liquid
- gold nanoparticles
- fluorescence imaging
- computed tomography
- high throughput
- dna damage
- high resolution
- dual energy
- transcription factor
- cell free
- label free
- energy transfer
- molecularly imprinted
- tandem mass spectrometry