The postnatal leptin surge in mice is variable in both time and intensity and reflects nutritional status.
Alicja A SkowronskiEvan D ShaulsonRudolph L LeibelCharles A LeDucPublished in: International journal of obesity (2005) (2021)
In mice, small litter size and maternal HFD feeding during the perinatal period augment the plasma leptin surge whereas large litter size is associated with a delayed surge of reduced magnitude.