Development of an LC-MRM-MS-Based Candidate Reference Measurement Procedure for Standardization of Serum Apolipoprotein (a) Tests.
L Renee RuhaakFred P H T M RomijnIlijana Begcevic BrkovicZsusanna KuklenyikJulia DittrichUta CeglarekAndrew N HoofnagleHarald AlthausEduardo Angles-CanoStefan CoassinVincent DelatourLiesbet DeprezIoannis DikaiosGerhard M KostnerFlorian KronenbergAlicia N LyleUrban PrinzingHubert W VesperChrista M CobbaertPublished in: Clinical chemistry (2023)
A robust, antibody-independent, MS-based cRMP was developed as higher order RMP and an essential part of the apo(a) traceability chain and future RMS. The cRMP fulfils predefined analytical performance specifications, making it a promising RMP candidate in an SI-traceable MS-based RMS for apo(a).