Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes.

Forough TorabiJayakumar VadakekolathuRebecca WyattPia LeeteMelissa A TombsCarolyn C RichardsonDavid J BoocockMark D TurnerNoel G MorganSarah J RichardsonMichael R Christie

Published in: Diabetic medicine : a journal of the British Diabetic Association (2023)

The results provide evidence that histologically-defined type 1 diabetes endotypes differ in their immunopathology and identify inflammatory pathways specifically involved in disease developing at a young age, essential for a better understanding of disease heterogeneity.

Keyphrases

type diabetes
cardiovascular disease
genome wide
oxidative stress
single cell
glycemic control
dna methylation
skeletal muscle
adipose tissue
transcription factor
weight loss
bioinformatics analysis