C-Glucosyl Xanthone Derivative Mangiferin Downregulates the JNK3 mediated caspase activation in Almal Induced Neurotoxicity in differentiated SHSY-5Y Neuroblastoma cells.

Nafila PkRavi Kumar Rajan Vanitha Nanchappan Arjunan Karuppiah Jaikanth Chandrasekaran Saravanan JayaramanVenkatesh Gunasekaran

Published in: Toxicology mechanisms and methods (2023)

Mangiferin demonstrated neuroprotection in SHSY-5Y cells against apoptosis induced by Almal by adapting the architecture of the neurons and increasing their density. Among all Xanthone derivatives, Mangiferin could improve neuronal toxicity by inhibiting JNK3 and down-regulating the Caspase activation.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
cell death
oxidative stress
signaling pathway
diabetic rats
pi k akt
cerebral ischemia
high glucose
spinal cord injury
subarachnoid hemorrhage