N,N' -Diarylurea Derivatives (CTPPU) Inhibited NSCLC Cell Growth and Induced Cell Cycle Arrest through Akt/GSK-3β/c-Myc Signaling Pathway.
Sunisa ThongsomSatapat RachaZin Zin EiKorrakod PetsriNithikoon AksornSupakarn ChamniVitsarut PanpuangHongbin ZouPithi ChanvorachotePublished in: International journal of molecular sciences (2023)
The results indicate that CTPPU significantly inhibits NSCLC cell proliferation by inducing G1/S cell cycle arrest via the Akt/GSK-3β/c-Myc signaling pathway. Molecular docking revealed that CTPPU could interact with Akt and mTORC2 molecules with a high binding affinity. These data indicate that CTPPU is a potential novel alternative therapeutic approach for NSCLC.
Keyphrases
- pi k akt
- cell cycle arrest
- signaling pathway
- cell proliferation
- molecular docking
- small cell lung cancer
- advanced non small cell lung cancer
- induced apoptosis
- epithelial mesenchymal transition
- molecular dynamics simulations
- brain metastases
- cell cycle
- high glucose
- diabetic rats
- electronic health record
- single cell
- epidermal growth factor receptor
- oxidative stress
- transcription factor
- mass spectrometry
- endothelial cells
- capillary electrophoresis
- endoplasmic reticulum stress
- dna binding
- structure activity relationship