Synthesis of α-CF3-substituted E-dehydroornithine derivatives via copper(i)-catalyzed hydroamination of allenes.

An efficient synthetic approach to novel α-CF3-substituted E-dehydroornithine derivatives and their phosphorus analogues has been developed via the Cu(i)-catalyzed hydroamination of trifluoromethyl-containing α-allenyl-α-aminocarboxylates and α-allenyl-α-aminophosphonates with primary and secondary amines.