IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
Zhenhua ZhangWim TrypsteenMarc BlaauwXiaojing ChuSofie RutsaertLinos VandekerckhoveWouter van der HeijdenJéssica Cristina Dos SantosCheng-Jian XuMorris A SwertzAndre van der VenYang LiPublished in: BMC medicine (2021)
The presented data suggests that the amount of CA HIV-1 DNA and RNA:DNA ratio can be influenced through PTDSS2, RNH1, and IRF7 that were anchored by our genome-wide association analysis. Further, these observations reveal potential host genetic factors affecting the size and transcriptional activity of HIV-1 reservoirs and could indicate new targets for HIV-1 therapeutic strategies.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- genome wide association
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- circulating tumor
- south africa
- single molecule
- gene expression
- genome wide
- transcription factor
- electronic health record
- machine learning
- deep learning
- data analysis
- human health