Association of BMAL1 clock gene polymorphisms with fasting glucose in children.
Yi-De YangYuan ZengJian LiJun-Hua ZhouQuan-Yuan HeChan-Juan ZhengChristoph ReichetzederBernhard K KrämerBerthold HocherPublished in: Pediatric research (2023)
Polymorphisms in the essential circadian clock gene BMAL1 were associated with fasting blood glucose levels in children. Additionally, there was a significant interaction between nutritional status and BMAL1 affecting fasting glucose levels. BMAL1 rs3789327 was associated with fasting glucose only in overweight/obese children. This finding could bring novel insights into mechanisms by which nutritional status influences fasting glucose in children.