Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51.
Fuqiang ChenWenna ZhaoChenghong DuZihan ChenJie DuMeijuan ZhouPublished in: Molecular medicine (Cambridge, Mass.) (2024)
Our works suggest that the inhibition of Rad51 plays a pivotal role in bleomycin-induced AECs senescence and lung injury, offering potential strategies to alleviate the pulmonary toxicity of bleomycin.