COVID-19 Associated Ketosis and Diabetic Ketoacidosis: A Rapid Review.

SARS-CoV-2 infection could disrupt the endocrine system directly or indirectly, which could result in endocrine dysfunction and glycemic dysregulation, triggering transient or persistent diabetes mellitus (DM). The literature on the complex relationship between COVID-19 and endocrine dysfunctions is still evolving and remains incompletely understood. Thus, we conducted a review on all literature to date involving COVID-19 associated ketosis or diabetic ketoacidosis (DKA). A total of 27 publications were included and analyzed quantitatively and qualitatively. Studies included DKA patients with existing or new onset diabetes. While the number of case and cohort studies was limited, DKA in the setting of COVID-19 seemed to increase risk of death, especially in new onset diabetes patients. Future studies with more specific variables and larger sample sizes are needed to draw better conclusions. This article is protected by copyright. All rights reserved.