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Sulforaphane activates CD8 + T cells antitumor response through IL-12RB2/MMP3/FasL-induced MDSCs apoptosis'.
Jinyan Liu
Huanan Chen
Caijuan Guo
Jieyao Li
Miaomiao Li
Ming Zhao
Ziyi Fu
Zhen Zhang
Feng Li
Xuan Zhao
Li Yang
Liping Wang
Quanjun Lv
Yi Zhang
Published in:
Journal for immunotherapy of cancer (2024)
T cells through IL-12RB2/MMP3/FasL induced apoptosis, thus providing a strategy for targeting MDSCs to control tumors and improve clinical efficacy.
Keyphrases
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induced apoptosis
endoplasmic reticulum stress
oxidative stress
diabetic rats
signaling pathway
high glucose
cell migration
cancer therapy
cell death
cell cycle arrest
endothelial cells
drug delivery
cell proliferation