Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury.

Zhongjie YiMeihong DengMelanie J ScottGuang FuPatricia A LoughranZhao LeiShilai LiPing SunChenxuan YangWenbo LiHongbo XuFeizhou HuangTimothy R Billiar

Published in: Hepatology (Baltimore, Md.) (2020)

Our data expand on the importance of IRG1/itaconate in nonimmune cells and identify itaconate as a potential therapeutic strategy for this unfavorable postsurgical complication.

Keyphrases

nuclear factor
ischemia reperfusion injury
toll like receptor
induced apoptosis
cell cycle arrest
oxidative stress
genome wide
copy number
cancer therapy
cell death
machine learning
gene expression
immune response
drug delivery
genome wide identification