On-Demand Activatable and Integrated Bioorthogonal Nanocatalyst against Biofilm-Associated Infections.
Yue SunHuisi ZhaoFang PuHao LiuLi ChenJinsong RenXiaogang QuPublished in: Advanced healthcare materials (2024)
Bioorthogonal chemistry has emerged as a powerful tool for manipulating biological processes. However, difficulties in controlling the exact location and on-demand catalytic synthesis limit its application in biological systems. Herein, this work constructs an activatable bioorthogonal system integrating a shielded catalyst and prodrug molecules to combat biofilm-associated infections. The catalytic species is activated in response to the hyaluronidase (HAase) secreted by the bacteria and the acidic pH of the biofilm, which is accompanied by the release of prodrugs, to achieve the bioorthogonal catalytic synthesis of antibacterial molecules in situ. Moreover, the system can produce reactive oxygen species (ROS) to disperse bacterial biofilms, enabling the antibacterial molecules to penetrate the biofilm and eliminate the bacteria within it. This study promotes the design of efficient and safe bioorthogonal catalysts and the development of bioorthogonal chemistry-mediated antibacterial strategies.
Keyphrases
- candida albicans
- pseudomonas aeruginosa
- staphylococcus aureus
- reactive oxygen species
- biofilm formation
- silver nanoparticles
- highly efficient
- cystic fibrosis
- crystal structure
- essential oil
- cancer therapy
- wound healing
- metal organic framework
- molecular dynamics
- density functional theory
- hyaluronic acid
- drug release
- visible light
- reduced graphene oxide