Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity.

Yi-Chen HsiehJoseph NegriAmy HeRichard V PearseLei LiuDuc M DuongLori B ChibnikDavid A BennettNicholas T SeyfriedTracy L Young-Pearse

Published in: Molecular neurodegeneration (2022)

The techniques and data herein introduce a system for modeling neuronal vulnerability in response to factors in the human brain and provide insights into proteins potentially contributing to AD pathogenesis.

Keyphrases

cerebral ischemia
climate change
electronic health record
nuclear factor
big data
immune response
subarachnoid hemorrhage
blood brain barrier
data analysis