Tandem aza-Michael addition-vinylogous aldol condensation: synthesis of N -bridged pyridine fused quinolones.
Lalitha GummidiAltaf MuddassarGangavaram V M SharmaV MurugeshSurisetti SureshPublished in: Organic & biomolecular chemistry (2022)
Herein, we present a tandem aza-Michael addition-vinylogous aldol condensation strategy for the synthesis of N -bridged pyridine fused quinolone derivatives from quinolones and ynones. The presented tandem transformation features the construction of C-N and CC bonds in a single operation, under transition metal-free conditions. The wide substrate scope and gram scale synthesis of pyridine fused quinolone derivatives expand the synthetic value of the presented protocol.