Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages.
Eng-Yen HuangJen-Chieh ChangHong-Hwa ChenChieh-Ying HsuHsuan-Chih HsuKeng-Liang WuPublished in: BMC cancer (2018)
Pretreatment CEA levels ≥10 ng/mL are a significant risk factor for OS, DM, and LR following PORT for rectal cancer. CEA causes radioresistance in the presence of M2 macrophages. More comprehensive examinations prior to surgery and intensive adjuvant therapy are suggested for patients with CEA levels ≥10 ng/mL. Further studies of these mechanisms are needed.
Keyphrases
- rectal cancer
- minimally invasive
- dna damage response
- locally advanced
- coronary artery bypass
- cancer stem cells
- squamous cell carcinoma
- type diabetes
- robot assisted
- radiation therapy
- adipose tissue
- acute coronary syndrome
- insulin resistance
- case control
- weight loss
- coronary artery disease
- skeletal muscle
- climate change
- glycemic control
- percutaneous coronary intervention