Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis.

Georgios D AyiomamitisGeorge NotasThivi VasilakakiAikaterini TsavariStyliani VederakiTheodosis TheodosopoulosElias KouroumalisApostolos Zaravinos

Published in: Cancers (2019)

Our data support that COX-2 is involved in the early stages of colorectal cancer development, initially affecting the tumor's stromal microenvironment, and, subsequently, the epithelial cells. They also highlight an inverse correlation between COX-2 expression and telomerase activity in CRC, as well as differentially methylated patterns within the promoter regions of COX-2 and TERT.

Keyphrases

stem cells
dna methylation
gene expression
bone marrow
transcription factor
big data
binding protein
machine learning
artificial intelligence
data analysis
deep learning