Atrial fibrillation represents the most frequent persistent cardiac arrhythmia and is associated with an increased morbidity and mortality. An important component of the holistic treatment of atrial fibrillation is oral anticoagulation (OAC) for the prevention of stroke. The CHA 2 DS 2 -VASc score as a risk score is recommended for estimation of the individual stroke risk and the concomitant need of OAC in these patients. In the majority of patients the OAC is nowadays carried out with direct oral anticoagulants (DOAC), which have proved to be effective with a moderate side effect profile and have replaced vitamin K antagonists as the standard substance. In the meantime, these principles have become established as the usual practice but some issues regarding OAC in patients with atrial fibrillation are still insufficiently answered. Furthermore, it is unclear whether OACs need to be continued after successful treatment of atrial fibrillation with pulmonary vein ablation or in some cases can even be discontinued. Unanswered questions also remain regarding the treatment of subclinical atrial fibrillation and atrial high-frequency episodes detected by implanted heart rhythm devices. Especially the duration of atrial high-frequency episodes that should trigger the initiation of OAC treatment is still under debate. Therefore, currently the benefits of stroke prevention must be carefully weighed up against the risk of bleeding complications.
Keyphrases
- atrial fibrillation
- catheter ablation
- direct oral anticoagulants
- high frequency
- left atrial
- oral anticoagulants
- left atrial appendage
- heart failure
- end stage renal disease
- transcranial magnetic stimulation
- percutaneous coronary intervention
- newly diagnosed
- chronic kidney disease
- ejection fraction
- venous thromboembolism
- prognostic factors
- primary care
- healthcare
- blood pressure
- patient reported outcomes
- smoking cessation
- left ventricular
- blood brain barrier
- quality improvement
- acute coronary syndrome
- coronary artery disease
- brain injury
- replacement therapy