Mechanisms Underlying the Cardioprotection of YangXinDingJi Capsule against Myocardial Ischemia in Rats.

Miaomiao LiuYurun XueYingran LiangYucong XueXue HanZiliang LiLi Chu

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

The results indicate that YXDJ significantly inhibited inflammatory cytokine expressions, oxidative stress, and L-type Ca2+ channels, and decreased contractility in isolated rat cardiomyocytes. These findings may be relevant to the cardioprotective efficacy of YXDJ.

Keyphrases

oxidative stress
diabetic rats
ischemia reperfusion injury
dna damage
induced apoptosis
left ventricular
smooth muscle
protein kinase
high glucose
heart failure
heat shock
endothelial cells
signaling pathway
endoplasmic reticulum stress