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A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy.

James McKiernanMikkel NoerholmVasisht TadigotlaSonia KumarPhillipp TorklerGrannum SantJason AlterMichael J DonovanJohan Skog
Published in: BMC urology (2020)
The EPI test provided good performance using the 15.6 cut-point for ruling out HGPCa / GG2 or higher in men undergoing a repeat prostate biopsy with a PSA of 2-10 ng/ml. Furthermore, the test utilizes gene expression data independent of clinical features to predict the likelihood of HGPCa / GG2 on a subsequent needle biopsy.
Keyphrases
  • prostate cancer
  • gene expression
  • ultrasound guided
  • fine needle aspiration
  • radical prostatectomy
  • high grade
  • dna methylation
  • middle aged
  • low grade
  • electronic health record
  • deep learning