Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus.
Reikou KamiyamaRyusuke YoshimiMitsuhiro TakenoYasuhiro IribeToshinori TsukaharaDaiga KishimotoYosuke KunishitaYumiko SugiyamaNaomi TsuchidaHiroto NakanoKaoru MinegishiMaasa TamuraYukiko AsamiYohei KirinoYoshiaki IshigatsuboKeiko OzatoHideaki NakajimaPublished in: Modern rheumatology (2018)
Our study showed ubiquitin-dependent proteasomal degradation of IRFs was impaired in anti-TRIM21 antibody-dependent and -independent fashions, leading to amplification of IFN signature in SLE.