Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.

Jingjing WangHuixin PengAyse Anil TimurVinay PasupuletiYufeng YaoTeng ZhangSun-Ah YouChun FanYubing YuXinzhen JiaJing ChenCheng-Qi Xu Qiuyun Chen Qing Kenneth Wang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2021)

We have identified integrin [alpha]5[beta]1 as an EC receptor for AGGF1 and a novel AGGF1-mediated signaling pathway of [alpha]5[beta]1-FAK-Src-AKT for angiogenesis. Our results identify an FQRDDAPAS angiogenic domain of AGGF1 crucial for its interaction with [alpha]5[beta]1 and signaling.

Keyphrases

endothelial cells
signaling pathway
vascular endothelial growth factor
pi k akt
high glucose
cell proliferation
cell migration
epithelial mesenchymal transition
wound healing
induced apoptosis
cell adhesion