HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.
Britta Franziska ZecherDavid EllinghausSebastian SchloerAnnika NiehrsBenedetta PadoanMartin E BaumdickYuko YukiMaureen P MartinDawid GlowJennifer Schröder-SchwarzJennifer NierschSébastien BriasLuisa M MüllerRobin HabermannPaul KretschmerTristan FrühJanis DänekasMalte H WehmeyerTobias PochMarcial Sebodenull nullEva EllinghausFrauke DegenhardtChristian KörnerAngelique HoelzemerBoris FehseKarl J OldhaferUdo SchumacherGuido SauterMary CarringtonAndre FrankeMadeleine J BundersSchramm ChristophMarcus AltfeldPublished in: Gut (2023)
and provide clinical and functional data implicating NKp44+NK cells that recognise HLA-DPA1*02:01-DPB1*01:01 expressed on cholangiocytes in PSC pathogenesis.