Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans.
Jonas Henrik KristensenRasmus Bo HasselbalchNina StrandkjærNicoline JørgensenMorten ØstergaardHasse Møller SørensenJens Christian NilssonShoaib AfzalPia Rørbæk KamstrupMorten DahlMustafa Vakur BorRuth Frikke-SchmidtNiklas Rye JørgensenLine RodeLene HolmvangJesper KjærgaardLia Evi BangJulie Lyng FormanKim Peder DalhoffAllan S JaffeKristian ThygesenHenning BundgaardKasper Karmark IversenPublished in: Circulation (2024)
This novel method showed that the elimination half-life of cTnI and cTnT was 5 to 16 hours shorter than previously reported. This indicates a considerably longer duration of cardiomyocyte cTn release after MI than previously thought. Improved knowledge of timing of myocardial injury may call for changes in the management of MI and other disorders with myocardial injury.
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