Antidepressant-resistant depression is characterized by reduced short- and long-interval cortical inhibition.

Jia-Shyun JengCheng-Ta LiHui-Ching LinShih-Jen TsaiYa-Mei BaiTung-Ping SuYu-Wen ChangChih-Ming Cheng

Published in: Psychological medicine (2019)

TRD was characterized by relatively reduced CI, including both GABAA- and GABAB-receptor-mediated neurons while non-TRD preserved partial CI. In non-TRD, SSRIs may mainly modulate GABAB-receptor-related LICI. Our findings revealed distinguishable features of CI in antidepressant-resistant and responsive major depression.

Keyphrases

major depressive disorder
depressive symptoms
spinal cord
cancer therapy
single cell
bipolar disorder
sleep quality
physical activity
drug delivery
spinal cord injury
binding protein
drug induced