Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide.
Adél SzerlauthTamara MadácsyGergely Ferenc SamuPéter BíróMiklós ErdélyiGábor VargaZhi Ping XuJózsef MaléthIstvan SzilagyiPublished in: Chemical communications (Cambridge, England) (2024)
Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase- and catalase-like activities in chemical assays, while proving as efficient antioxidants in the reduction of intracellular oxidative stress. The results indicate the great promise of CMA in antioxidant therapies.
Keyphrases
- oxidative stress
- reactive oxygen species
- aqueous solution
- dna damage
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- reduced graphene oxide
- quantum dots
- high throughput
- ionic liquid
- metal organic framework
- hydrogen peroxide
- big data
- nitric oxide
- heat shock
- gold nanoparticles
- signaling pathway
- artificial intelligence