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Progress in research on the role played by myeloid-derived suppressor cells in liver diseases.

Qianqian SunHeng DaiSiliang WangYuanyuan ChenHuilian Shi
Published in: Scandinavian journal of immunology (2023)
Myeloid-derived suppressor cells (MDSCs) refer to a group of immature myeloid cells with potent immunosuppressive capacity upon activation by pathological conditions. Because of their potent immunosuppressive ability, MDSCs have garnered extensive attention in the past few years in the fields of oncology, infection, chronic inflammation and autoimmune diseases. Research on MDSCs in liver diseases has gradually increased, and their potential therapeutic roles will be further explored. This review presents a summary of the involvement and the role played by MDSCs in liver diseases, thus identifying their potential targets for the treatment of liver diseases and providing new directions for liver disease-related research.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • endoplasmic reticulum stress
  • cell death
  • acute myeloid leukemia
  • immune response
  • cell proliferation
  • drug induced
  • human health