Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
Xiaowei MaGe BaiDifei LuLinjuan HuangJianwei ZhangRuifen DengShan DingNan GuXiaohui GuoPublished in: Journal of diabetes research (2017)
Background. Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system. This study aimed to investigate whether genetic variations in the STK11 gene affect the risk of coronary artery disease (CAD) in Chinese type 2 diabetics. Methods. 5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases and 159 CAD-negative controls with type 2 diabetes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results. The carriers of minor allele A at rs12977689 had a higher risk of CAD compared to the homozygotes of CC (OR = 1.572, 95% CI = 1.039-2.376, p = 0.035), and the difference was still significant after adjustment for the other known CAD risk factors (OR' = 1.184, 95% CI' = 1.036-1.353, p' = 0.013). Conclusion. Genetic variability at STK11 locus is associated with CAD risk in type 2 diabetes in the Chinese population.
Keyphrases
- coronary artery disease
- protein kinase
- type diabetes
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- genome wide
- risk factors
- copy number
- glycemic control
- cardiovascular disease
- aortic stenosis
- metabolic syndrome
- insulin resistance
- transcription factor
- left ventricular
- heart failure
- adipose tissue
- aortic valve