Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis.

Alexander J Knights Easton C FarrellOlivia M EllisMichelle J SongChristopher Thomas Appleton Tristan Maerz

Published in: bioRxiv : the preprint server for biology (2023)

We defined different synovial macrophage subpopulations present in healthy and injured mouse synovium. Nuanced characterization of the distinct functions, origins, and disease kinetics of macrophage subtypes in PTOA will be critical for targeting these highly versatile cells for therapeutic purposes.

Keyphrases

adipose tissue
induced apoptosis
cell cycle arrest
rheumatoid arthritis
endoplasmic reticulum stress
signaling pathway
pi k akt