Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Shuang G ZhaoWilliam S ChenRajdeep DasS Laura ChangScott A TomlinsJonathan ChouDavid A QuigleyHa X DangTravis J BarnardBrandon A MahalEwan A GibbYang LiuElai Davicioni Linda R Duska Edwin M PosadasShruti JollyDaniel E SprattPaul L NguyenChristopher A MaherEric J SmallFelix Y Feng

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

This first pan-carcinoma luminal/basal subtyping across epithelial tumors reveals global similarities across carcinomas in the transcriptome, genome, clinical outcomes, and drug sensitivity, emphasizing the biological and translational importance of these luminal versus basal subtypes.

Keyphrases

high grade
genome wide
gene expression
single cell
copy number
dna methylation
emergency department
electronic health record