PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion.

Sheng LeHao ZhangXiaofan HuangShu ChenJia WuShanshan ChenXiangChao DingShanshan ChenJing ZhaoHeng XuJikai CuiYanqiang ZouJizhang YuLang JiangJie WuPing YeJiahong Xia

Published in: Journal of cardiovascular pharmacology and therapeutics (2020)

Pyruvate kinase M2 plays a protective role in TAAD development, and its activation is a promising therapeutic strategy against the progression of TAAD.

Keyphrases

nlrp inflammasome
aortic aneurysm
spinal cord
signaling pathway
nuclear factor
protein kinase
tyrosine kinase
toll like receptor
spinal cord injury
immune response
inflammatory response