Application of nanomaterials in the treatment of intracerebral hemorrhage.
Xiangyu ZhangSuliman KhanRuixue WeiYan ZhangYang LiuVoon Wee YongMengzhou XuePublished in: Journal of tissue engineering (2023)
Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by the rupture of blood vessels in the brain parenchyma, with an acute mortality rate of 30%‒40%. Currently, available treatment options that include surgery are not promising, and new approaches are urgently needed. Nanotechnology offers new prospects in ICH because of its unique benefits. In this review, we summarize the applications of various nanomaterials in ICH. Nanomaterials not only enhance the therapeutic effects of drugs as delivery carriers but also contribute to several facets after ICH such as repressing detrimental neuroinflammation, resisting oxidative stress, reducing cell death, and improving functional deficits.
Keyphrases
- cell death
- oxidative stress
- brain injury
- traumatic brain injury
- minimally invasive
- spinal cord injury
- cerebral ischemia
- liver failure
- coronary artery bypass
- dna damage
- drug induced
- cardiovascular events
- respiratory failure
- type diabetes
- risk factors
- subarachnoid hemorrhage
- lps induced
- cognitive impairment
- aortic dissection
- ischemia reperfusion injury
- coronary artery disease
- cardiovascular disease
- induced apoptosis
- combination therapy
- intensive care unit
- replacement therapy
- multiple sclerosis
- signaling pathway
- heat stress
- acute respiratory distress syndrome
- heat shock protein