Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis.
Kathryn E LafondRachael M PorterMelissa J WhaleyZhou SuizanZhang RanMohammad Abdul AleemBinay Thapa ThapaBorann SarViviana Sotomayor ProschleZhibin PengLuzhao FengDaouda CoulibalyEdith NkwembeAlfredo OlmedoWilliam K AmpofoSiddhartha SahaMandeep ChadhaAmalya MangiriVivi SetiawatySami Sheikh AliSandra S ChavesDinagul OtorbaevaOnechanh KeosavanhMajd SalehAntonia Ying Wai HoBurmaa AlexanderHicham OumzilKedar Prasad BaralQ Sue HuangAdedeji A AdebayoIdris Al-AbaidaniMarta von HorochCheryl CohenStefano TempiaVida MmbagaMalinee ChittaganpitchMariana G CasalDuc Anh DangPaula CoutoHarish NairJoseph S BreseeSonja J OlsenEduardo Azziz-BaumgartnerJ Pekka NuortiMarc-Alain Widdowsonnull nullPublished in: PLoS medicine (2021)
In this meta-analysis, we estimated that influenza viruses are associated with over 5 million hospitalizations worldwide per year. Inclusion of both published and unpublished findings allowed for increased power to generate stratified estimates, and improved representation from lower-income countries. Together, the available data demonstrate the importance of influenza viruses as a cause of severe disease and hospitalizations in younger and older adults worldwide.