Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.
Golo KronenbergMarkus PetermannChristof DormannMichael BaderPeter GassRainer HellwegFriederike KlempinPublished in: European archives of psychiatry and clinical neuroscience (2018)
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.
Keyphrases
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- resting state
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- major depressive disorder
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- insulin resistance
- subarachnoid hemorrhage
- metabolic syndrome
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- endothelial cells
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- bone marrow
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- drug induced
- cell therapy