Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants.
Evelyn HoutmanMargo TuerlingsJanne RiechelmanEka H E D SuchimanRobert J P van der WalRob G H H NelissenHailiang MeiYolande F M RamosRodrigo Coutinho de AlmeidaIngrid MeulenbeltPublished in: Arthritis research & therapy (2021)
Our results faithfully represent transcriptomic wide consequences of mechanical stress in human aged articular cartilage with MMP13, IGF binding proteins, and cellular senescence as the most notable results. Acquired knowledge on the as such identified initial, osteoarthritis-related, detrimental responses of chondrocytes may eventually contribute to the development of effective disease-modifying osteoarthritis treatments.