Cellular contribution to left and right atrial dysfunction in chronic arterial hypertension in pigs.

Jin Ge Martin Manninger Gabriel AdelsmayrMichael SchwarzlAlessio AlognaPatrick SchönleitnerDavid ZweikerFlorian BlaschkeMohammad SherifSnjezana RadulovicPaulina WakulaSylvia SchauerGerald HöflerUrsula ReiterGert ReiterHeiner PostDaniel ScherrKaroly AcsaiGudrun AntoonsBurkert Pieske Frank R Heinzel

Published in: ESC heart failure (2020)

In this large animal model of HHD, atrial remodelling in sinus rhythm in vivo was related to differential LA and RA cardiomyocyte dysfunction and Ca signalling. Selective acute inhibition of NCX improved Ca release in diseased LA cardiomyocytes, suggesting a potential therapeutic approach to improve atrial inotropy in HHD.

Keyphrases

atrial fibrillation
arterial hypertension
left atrial
catheter ablation
oxidative stress
drug induced
liver failure
rheumatoid arthritis
heart failure
respiratory failure
high glucose
heart rate
mitral valve
ankylosing spondylitis
disease activity
left ventricular
idiopathic pulmonary fibrosis